| Pair Name | Paeonol, Epirubicin | ||
| Phytochemical Name | Paeonol (PubChem CID: 11092 ) | ||
| Anticancer drug Name | Epirubicin (PubChem CID: 41867 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Epirubicin |
| Adverse Reactions | Nausea, vomiting, diarrhoea, loss of appetite, inhibition of bone marrow haematopoiesis. This was inferred cold nature anticancer drug. |
| Recommendations | Hot: Pinellia ternata |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Paeonol, Epirubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Up-regulation | Cleavage | PARP1 | hsa142 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | MAPK14 | hsa1432 | |
| Down-regulation | Expression | MAPK8 | hsa5599 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 | |
| Result | These findings suggest that combination of Paeonol and Epirubicin is potentially applicable for breast cancer treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhanced antitumor activity and attenuated cardiotoxicity of Epirubicin combined with Paeonol against breast cancer. Tumour Biol. 2016 Sep;37(9):12301-12313. doi: 10.1007/s13277-016-5088-9. | Click |
